Auditory nerve preservation and regeneration in man:relevance for cochlear implantation

作     者：Helge Rask-Andersen Wei Liu 

作者机构：Department of Surgical SciencesHead and Neck SurgerySection of OtolaryngologyUppsala University Hospital Departments of OtolaryngologyUppsala University Hospital 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第5期

页      面：710-712页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by ALF grants from Uppsala University Hospital and Uppsala University the Foundation of "Tysta Skolan",Swedish Deafness Foundation (HRF) kind private funds from Brje Rungrd,Sweden 

主　　题：cell Auditory nerve preservation and regeneration in man 

摘      要：Human hearing relies on 15,000 hair cells （HCs） or mecha- noreceptors sited in a 34 mm long helical shaped epithelial ridge. There may be several explanations for their vulner- ability in man and regrettably, they do not regenerate. Ap- proximately 35,000 bipolar neurons have their soma situated in the modiolus of the cochlea. Human afferents consist of two separate systems; one is represented by the large type I cells innervating the inner HCs （IHCs, n = 3,400） and the other one by the small type Ⅱcells innervating the outer HCs （OHCs, n = 12,000）. Type I spiral ganglion neurons （SGNs） constitute 96% of the afferent nerve population. Unlike in other mammals, their somas together with the pre- and post-somatic segments are unmyelinated. Type II nerve cell soma and fibers are unmyelinated.