Farnesoid X receptor regulators from natural products and their biological function

作     者：PENG Wan NI Hengfan GUO Dale DENG Yun DAI Manyun PENG Wan;NI Hengfan;GUO Dale;DENG Yun;DAI Manyun

作者机构：Institute of Rare DiseasesWest China HospitalSichuan UniversityChengdu 610065China Department of PharmacyWest China HospitalSichuan UniversityChengdu 610041China School of PharmacyChengdu University of Traditional Chinese MedicineState Key Laboratory of Southwestern Chinese Medicine ResourcesChengdu 611137China School of MedicineNingbo UniversityNingbo 315000China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第3期

页      面：618-626页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China:Study on Coptidis Rhizoma’s Therapeutic Mechanism of Diabetes Mellitus and Innovation of Relative Drug based on DNA Encoded Compound Library Technology(No.U19A2011) Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine:Discovery of Active Components Reshaping Tumor Immune Microenvironment Based on Feature Gene Expression Profile of Sichuan’s Characteristic Medicinal Materials(No.ZDZX2022002) 

主　　题：farnesoid X receptor metabolic syndrome biological products molecular docking simulation biological activity 

摘      要：Metabolic syndrome(Met S)has been a growing public health concern worldwide without specific *** summarizing the chemical structure type and effect mechanisms of natural products targeted on farnesoid X receptor(FXR),to provide the research basis for exploring the treatment of Met *** following databases were searched for natural products which targeting FXR:Pub Med,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,and Chinese Biomedical Literature *** 120 natural products were summarized,including terpenoids(51 compounds),steroidal saponins(27 compounds),phenylpropanolds(19 compounds),flavonoids(13 compounds),alkaloids(3 compounds)and others(7 compounds),most researches focus on terpenoids and part of synthetic FXR regulators were based on the structure of *** regulators could improve cholestasis and liver injury,hyperlipidemia,diabetes and *** is a potential target of treating Met *** products are characteristics with unique novel structures and special biological activity,and they are important sources of bioactive precursor compounds and drug *** the effects and mechanism of natural products and its derivative on Met S by targeting FXR may be a new way to develop the new drugs of treating Met S.