Microbial synthesis of bacitracin:Recent progress,challenges,and prospects
作者机构：State Key Laboratory of Biocatalysis and Enzyme EngineeringEnvironmental Microbial Technology Center of Hubei ProvinceCollege of Life SciencesHubei UniversityWuhan430062PR China Hubei Provincial Key Laboratory of Industrial MicrobiologyKey Laboratory of Fermentation Engineering(Ministry of Education)School of Food and Biological EngineeringHubei University of TechnologyWuhan430068HubeiPR China Lifecome Biochemistry Co.LtdNanping353400PR China
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2023年第8卷第2期
页 面：314-322页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by National Key Research and Development Program of China(2022YFA0911800) Knowledge Innovation Program of Wuhan-Shuguang Project(2022020801020334) Science and Technology Project of Hubei Tobacco Company(027Y2021-023,027Y2020-013)
主 题：Bacillus Bacitracin Metabolic regulation Metabolic engineering Fermentation process
摘 要：Microorganisms are important sources of various natural products that have been commercialized for human medicine and animal *** is an important antibacterial natural product predominantly pro-duced by Bacillus licheniformis and Bacillus subtilis,and it is characterized by a broad antimicrobial spectrum,strong activity and low resistance,thus bacitracin is extensively applied in animal feed and veterinary medicine *** recent years,various strategies have been proposed to improve bacitracin ***,we systematically describe the regulation of bacitracin biosynthesis in genus Bacillus and its associated mechanism,to provide a theoretical basis for bacitracin *** metabolic engineering strategies applied for bacitracin production are explored,including improving substrate utilization,using an enlarged precursor amino acid pool,increasing ATP supply and NADPH generation,and engineering transcription *** also present several approaches of fermentation process optimization to facilitate the industrial large-scale production of ***,the challenges and prospects associated with microbial bacitracin synthesis are discussed to facilitate the establishment of high-yield and low-cost biological factories.
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