Lower Baseline LDL Cholesterol Affects All-cause Mortality in Patients with First Percutaneous Coronary Intervention

作     者：CHEN Xi CHEN Hao LU Wei Bo ZHANG Min TAO Yuan WANG Qing Cheng FU Guo Sheng ZHANG Wen Bin CHEN Xi;CHEN Hao;LU Wei Bo;ZHANG Min;TAO Yuan;WANG Qing Cheng;FU Guo Sheng;ZHANG Wen Bin

作者机构：Center for General Practice MedicineDepartment of General Practice MedicineZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeSchool of the Second Clinical MedicineHangzhou Normal UniversityHangzhou 310014ZhejiangChina Department of Cardiovascular DiseasesSir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310020ZhejiangChina Shengzhou People's Hospital(The First Afiliated Hospital of Zhejiang University Shengzhou Branch)Shengzhou 312499ZhejiangChina Collaborative Innovation Center of Seafood Deep ProcessingZhejiang Province Joint Key Laboratory of Aquatic Products ProcessingInstitute of SeafoodZhejiang Gongshang UniversityHangzhou 310012ZhejiangChina Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106ZhejiangChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2023年第36卷第4期

页      面：324-333页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Ethics Committee of Sir Run Run Shaw Hospital of Zhejiang University [NO.20200224-33] Key Project of Medical and Health Science and Technology of Zhejiang Province [NO. WKJ-ZJ-1715] Zhejiang Province Traditional Chinese Medicine Science and Technology Project [NO. 2017ZA006] Natural Science Foundation of Zhejiang Province [NO. LQ17H020006] Medical health Science and Technology project of Zhejiang Province [NO. 2017KY207] National Natural Science Foundation of China Medical and health project [2021RC014] Hangzhou Medical Health Science and Technology Project [B20200116] “Pioneer” and “Leading Goose” R&D Program of Zhejiang[2023C04013] Administration of Traditional Chinese Medicine of Zhejiang Province [GZY-ZJ-KJ-23001] 

主　　题：Low-density lipoprotein cholesterol Coronary artery disease Clinical outcomes 

摘      要：Objective Foreign studies have reported that coronary artery disease(CAD) patients with high baseline low-density lipoprotein cholesterol(LDL-C) may have a good prognosis, which is called the “cholesterol paradox. This study aimed to examine whether the “cholesterol paradox also exists in the Chinese *** A total of 2,056 patients who underwent the first percutaneous coronary intervention(PCI)between 2014 and 2016 were enrolled in this retrospective cohort study and classified into two groups based on baseline LDL-C = 2.6 mmol/L(100 mg/d L). The outcomes of interest included major adverse cardiovascular events(MACE), all-cause mortality, recurrent nonfatal myocardial infarction, unexpected coronary revascularization, or any nonfatal *** All-cause mortality occurred in 8 patients(0.7%) from the low-LDL-C group and 12 patients(2.4%) in the high-LDL-C group, with a significant difference between the two groups(adjusted hazard ratio: 4.030, 95% confidence interval: 1.088–14.934;P = 0.037). However, no significant differences existed for the risk of MACE or other secondary endpoints, such as unexpected revascularization, nor any nonfatal stroke in the two *** In this study, a high baseline LDL-C was not associated with a low risk of clinical outcomes in CAD patients undergoing first PCI, which suggested that the “cholesterol paradox may be inapplicable to Chinese populations.