A CS-based composite scaffold with excellent photothermal effect and its application in full-thickness skin wound healing

作     者：Jing Wang Shijia Fu Huishan Li Yue Wu 

作者机构：School of Life SciencesNorthwestern Polytechnical UniversityXi’an 710072China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：784-798页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(31900948) 

主　　题：skin regeneration chitosan carbon nanotubes hydroxyapatite nanoparticles photothermal effect 

摘      要：The development of natural polymer-based scaffolds with excellent biocompatibility,antibacterial activity,and blood compatibility,able to facilitate full-thickness skin wound healing,remains *** this study,we have developed three chitosan(CS)-based porous scaffolds,including CS,CS/CNT(carbon nanotubes)and CS/CNT/HA(nano-hydroxyapatite,n-HA)using a freeze-drying *** three scaffolds have a high swelling ratio,excellent antibacterial activity,outstanding cytocompatibility and blood compatibility in *** introduction of CNTs exhibited an obvious increase in mechanical properties and exerts excellent photothermal response,which displays excellent healing performance as a wound dressing in mouse full-thickness skin wound model when compared to CS ***/CNT/HA composite scaffolds present the strongest ability to promote full-thickness cutaneous wound closure and skin regeneration,which might be ascribed to the synergistic effect of photothermal response from CNT and excellent bioactivity from ***,the present study indicated that CNT and n-HA can be engineered as effective constituents in wound dressings to facilitate full-thickness skin regeneration.