Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin
作者机构：Institute of Functional SurfacesSchool of Mechanical EngineeringUniversity of LeedsLeeds LS29JTUnited Kingdom Reliability Engineering InstituteNational Engineering Research Center for Water Transport SafetyWuhan University of TechnologyWuhan 430063China
出 版 物：《Friction》 (摩擦（英文版）)
年 卷 期：2023年第11卷第4期
页 面：617-634页
核心收录：
学科分类：0710[理学-生物学] 081702[工学-化学工艺] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：supported by the International Postdoctoral Exchange Fellowship Program(Grant No.20190060)。
主 题：lubrication mucin polyethylene glycol mucoadhesive chemisorption
摘 要：Mucins are vital components contributing to the unique lubrication properties of human whole saliva.For patients receiving medication and or treatment such as diabetes or radiotherapy,xerostomia(dry mouth)is a common with numerous and deleterious side effects.Although products exist on the market to relive the symptoms of Xerostomia there remains a drive to formulate a biocompatible lubricant that replicate the functionality offered by the natural biological environment.Herein,a combination of mucin and thiolated polyethylene glycol(PEG-SH)was proposed as a new saliva substitute.Mucin and PEG-SH molecules could form hydrated layers immediately by chemisorption.Meanwhile,the chemical interactions between mucin and PEG-SH molecules also promoted the formation of a mixed layer.All the pre-formed layers could decrease friction and had the potential to decrease wear,especially mucin and PEG-SH mixed layer when compared to mucin only solutions.Further investigations of tribological mechanism implied that the excellent lubrication performance of mixed layer with long effectiveness was contributed to the frictionreducing effect of PEG/mucin molecules and the mucoadhesive property of mucin.The study provides a guide for using mucin as a mucoadhesive agent to stable lubricative polymers with low molecular weight as novel salivary substitutes for lubrication.
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