Pyroptosis and its role in cancer
作者机构：Department of Joint SurgeryDalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of OncologyThe First Affiliated Hospital of Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Joint SurgeryThe Second Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2023年第11卷第11期
页 面：2386-2395页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pyroptosis Caspase-1/3/4/5/11 Gasdermin family Cancer
摘 要：Programmed cell death(PCD)is mediated by specific genes that encode *** can balance cell survival and *** is a type of inflammatory,caspase-dependent PCD mediated by gasdermin proteins,which function in pore formation,cell expansion,and plasma membrane rupture,followed by the release of intracellular *** is mediated by caspase-1/3/4/5/11 and is primarily divided into the classical pathway,which is dependent on caspase-1,and the non-classical pathway,which is dependent on caspase-4/5/***-masomes play a vital role in these *** various components of the pyroptosis pathway are related to the occurrence,invasion,and metastasis of *** on pyroptosis has revealed new options for tumor *** article summarizes the recent research progress on the molecular mechanism of pyroptosis,the relationship between the various components of the pyroptosis pathway and cancer,and the applications and prospects of pyroptosis in anticancer therapy.
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