Red blood cell distribution width is associated with in-hospital mortality in sepsis with MRSA infection in MIMIC-Ⅳ

作     者：Song Kun Song Yaqin Ding Ning Li Changluo Song Kun;Song Yaqin;Ding Ning;Li Changluo

作者机构：Department of Emergency MedicineThe Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South China 

出 版 物：《实用休克杂志（中英文）》 (Journal of Practical Shock)

年 卷 期：2022年第6卷第6期

页      面：377-384页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：RDW Sepsis MRSA MIMIC-Ⅳ 

摘      要：Background This study aimed to explore the associations of factors with in-hospital mortality in sepsis with MRSA infection based on the MIMIC-Ⅳdatabase.Methods All sepsis patients with MRSA infection were included.Multivariate regression analysis was applied to identify predictive factors.Models were applied to explore the relationship between the factors and in-hospital mortality after adjusting potential cofounders.Results A total of 157 patients were included including a survivor group(n=111)and a non-survivor group(n=46)were included.RDW was identified as an independent factor with in-hospital mortality.A smooth fitting curve for a positive linear relationship between RDW and in-hospital mortality was constructed.The area under the ROC curve(AUC)was 0.652 with a sensitivity of 0.565 and a specificity of 0.676.The optimal cut-off value of RDW was 16.55.Compared with SOFA and APACHEⅡscores,RDW had a better predictive performance.Conclusion RDW was associated with clinical outcomes in sepsis with MRSA infection.