Grape seed extract improves intestinal barrier integrity and performance: Evidence from in vitro, Caenorhabditis elegans and Drosophila melanogaster experiments and a study with growing broilers
作者机构：Center of Excellence Food Technology and NutritionUniversity of Applied Sciences Upper AustriaStelzhamerstraße 23Wels4600Austria FFoQSI GmbH-Austrian Competence Centre for Feed and Food QualitySafety and InnovationTechnopark 1DTulln3430Austria Delacon Biotechnik GmbHLangwiesen 24Engerwitzdorf4209Austria
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2023年第52卷第2期
页 面：1128-1136页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Austrian Competence Centre for Feed and Food Quality Austrian ministries BMVIT Österreichische Forschungsförderungsgesellschaft, FFG, (868740) Christian Doppler Forschungsgesellschaft, CDG Bundesministerium für Digitalisierung und Wirtschaftsstandort, BMDW
主 题：Intestinal functionality Intestinal barrier Grape seed extract C.elegans D.melanogaster Broiler Oxidative stress
摘 要：Grape seed extract(GSE)is an interesting source for polyphenols and other phytochemicals with high antioxidant ***,we report on a comprehensive study investigating GSE in various in vitro and in vivo *** results indicate that GSE improves parameters related to intestinal barrier integrity in cell culture,*** and *** wound healing was observed in a scratch assay using intestinal IPEC-J2 cells when pre-treated with ***,reactive oxygen species were found to be significantly decreased in cell culture and *** *** ***,qPCR gene expression analysis revealed significant modulations after 24 h of GSE ***,a 42-day broiler feeding study revealed a dose dependant effect on growth performance in the GSE supplemented *** conclusion,GSE was found to provide promising properties including wound closure,intestinal integrity,and antioxidant activity.
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