The dichotomous role of immunoproteasome in cancer:Friend or foe?

作     者：Boya Chen Haiying Zhu Bo Yang Ji Cao Boya Chen;Haiying Zhu;Bo Yang;Ji Cao

作者机构：Institute of Pharmacology and ToxicologyZhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China The Innovation Institute for Artificial Intelligence in MedicineZhejiang UniversityHangzhou 310058China Cancer Center of Zhejiang UniversityHangzhou 310058China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第5期

页      面：1976-1989页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：grants from National Natural Science Foundation of China(No.81930102 to Bo Yang) Zhejiang Provincial Natural Science Foundation(No.LR22H310002 to Ji Cao,China) Zhejiang University K.P.Chao's High Technology Development Foundation(China) 

主　　题：Immunoproteasome Ubiquitin—proteasome system Antigenic peptides Proteolysis Cancer Immunotherapy Proteasome inhibitor Targeted therapy 

摘      要：Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex(MHC)-I *** from this primary function in antigen presentation,immunoproteasome is also responsible for the degradation of proteins,both unfolded proteins for the maintenance of protein homeostasis and tumor suppressor proteins contributing to tumor *** altered expression of immunoproteasome is frequently observed in cancers;however,its expression levels and effects vary among different cancer types exhibiting antagonistic roles in tumor *** review focuses on the dichotomous role of immunoproteasome in different cancer types,as well as summarizes the current progression in immunoproteasome activators and *** targeting immunoproteasome may be a beneficial therapeutic intervention in cancer treatment and understanding the role of immunoproteasome in cancers will provide a significant therapeutic insight for the prevention and treatment of cancers.