Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy
作者机构：State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China
出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)
年 卷 期：2023年第17卷第4期
页 面：483-489页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学]
基 金：supported by the Major State Basic Research Development Program of China (Grant No.2017YFA0205201) the National Natural Science Foundation of China (Grant Nos.81925019 and U1705281).
主 题：bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch
摘 要：Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process,the bioorthogonal reaction that commonly contains the“bond formationand“bond cleavagesystem has been widely used in targeted therapy for a variety of tumors.Herein,several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy,and the innovative tactics for reducing the metal ions’toxic and side effects with microneedle patches will be highlighted.Based on these applications,the complexities,potential pitfalls,and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.
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