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High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic postischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord

作     者:Xin Jia Ziyang Li Xiafeng Shen Yu Zhang Li Zhang Ling Zhang Xin Jia;Ziyang Li;Xiafeng Shen;Yu Zhang;Li Zhang;Ling Zhang

作者机构:Department of Neurology and Neurological RehabilitationShanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Department of RehabilitationShanghai Pudong HospitalFudan University Pudong Medical CenterShanghaiChina Key Laboratory of Cellular Physiology(Shanxi Medical University)Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuanShanxi ProvinceChina Key Laboratory of Central CNS Regeneration(Ministry of Education)Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina 

出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))

年 卷 期:2023年第18卷第11期

页      面:2535-2544页

核心收录:

学科分类:0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基  金:National Key R&D Program of China,Nos.2019YFA0110300 (to LZ),2021YFA1201400 (to LZ) Natural Science Foundation of Shanghai,No.21ZR1468600 (to LZ) Open Fund of the Key Laboratory of Cellular Physiology (Shanxi Medical University),Ministry of Education,No.KLMEC/SXMU-201910 (to XJ)。 

主  题:central sensitization chemerin receptor 23 chronic post-ischemia pain complex regional pain syndrome exercise-induced analgesia microglia neuroinflammation resolvin E1 spinal cord swimming 

摘      要:Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.

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