Effects of functionally graded materials on dynamics of molecular bond clusters

作     者：ZHANG WenLiang QIAN Jin YAO HaiMin CHEN WeiQiu GAO HuaJian 

作者机构：Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China Soft Matter Research CenterZhejiang UniversityHangzhou 310027China Department of Mechanical EngineeringHong Kong Polytechnic UniversityHong KongChina School of EngineeringBrown UniversityProvidenceRI 02912USA 

出 版 物：《Science China(Physics,Mechanics & Astronomy)》 (中国科学：物理学、力学、天文学（英文版）)

年 卷 期：2012年第55卷第6期

页      面：980-988页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：supported by the Start-up Funding from Young Thousand-Talent Program of China the Fundamental Research Funds for Central Universities (Grant No. 2011XZZX002) the National Natural Science Foundation of China (Grant No. 11072273) 

主　　题：graded material adhesion molecular bond stiffness gradation 

摘      要：Unlike nonspecific adhesion of conventional hard materials in engineering commonly described by JKR and DMT type models,the molecular adhesion via specific receptor-ligand bonds is stochastic by nature and has the feature that its strength strongly depends on the medium stiffness surrounding the *** this paper,we demonstrate in a stochastic-elasticity framework that a type of materials with linearly graded elastic modulus can be designed to achieve equal load sharing and enhanced cooperative rebinding among interfacial molecular *** modulus gradation,multiple molecular bonds can be elastically decoupled but statistically *** general,uniform molecular adhesion can be accomplished by two strategies:homogeneous materials with sufficient stiffness higher than a threshold or heterogeneous materials satisfying the criterion on modulus *** results not only provide a theoretical principle for possible applications of functionally graded materials in quantitatively controlling cell-matrix adhesion,but also have general implications on adhesion between soft materials mediated by specific molecular binding.