Cysteine-activated fluorescence/photoacoustic integrated probe for non-invasive diagnosis of drug-induced liver injury

作     者：Rui Chen Wenxiu Li Rong Li Sixin Ai Huayong Zhu Weiying Lin Rui Chen;Wenxiu Li;Rong Li;Sixin Ai;Huayong Zhu;Weiying Lin

作者机构：Guangxi Key Laboratory of Electrochemical Energy MaterialsInstitute of Optical Materials and Chemical BiologySchool of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第5期

页      面：484-488页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(Nos.21672083,21877048,22077048) Natural Science Foundation of Guangxi(Nos.2021GXNSFDA075003,AD21220061) the Startup Fund of Guangxi University(No.A3040051003) 

主　　题：Near-infrared fluorescence Photoacoustic imaging Fluorescence imaging Cysteine 

摘      要：Hepatotoxicity is a serious problem faced by clinical drugs,and long-term administration or overdose may lead to liver failure and even death of ***,developing a reliable detection method for the early diagnosis and therapy of drug-induced liver injury(DILI)has significant *** fluorescence(NIRF)and photoacoustic(PA)dual-modality tomography probes can be used for imaging with high sensitivity and high-resolution of disease-related markers in deep ***,we developed a novel Cys-activated NIRF and PA dual-modality imaging probe(CDR)for early diagnosis of DILI,for the first *** organic molecular probe CDR could respond rapidly to Cys,resulting in the absorption peak red-shifted from 560 nm to 725 nm,which also leads to the activation of the PA725signal and *** addition,the new probe CDR could be used for NIRF/PA imaging of exogenous and endogenous Cys level in live cells and *** importantly,CDR has also been successfully used for in situ detection of Cys in early DILI mice and evaluate the therapeutic effect of ***,the CDR might become a powerful tool to research the physiological effect of Cys and evaluate the degree of DILI.