A high-fat diet reverses improvement in glucose tolerance induced by duodenal-jejunal bypass in type 2 diabetic rats

作     者：LIU Shao-zhuang SUN Dong ZHANG Guang-yong WANG Lei LIU Teng SUN Yu LI Ming-xia HU San-yuan 

作者机构：Department of General SurgeryQiluHospital of Shandong University Jinan Shandong250012 China L Liu T and Hu SY） Department of Endocrinology QiluHospital of Shandong University Jinan Shandong 250012 China Experimental Center School of Chemistry and ChemicalEngineering Shandong University Jinan Shandong 250399China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第5期

页      面：912-919页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China (No. 81070642/H0713)  the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20100131110049) and the Graduate Independent Innovation Foundation of Shandong University (No. yzc09094  No. yzcl1068) 

主　　题：duodenal-jejunal bypass type 2 diabetes mellitus," recurrence," glucagon-like peptide-1 

摘      要：Background Bariatric surgery offers successful resolution of type 2 diabetes mellitus （T2DM）. However, recurrence of T2DM has been observed in a number of patients with initial resolution after bariatric surgery. This study aimed to induce reversal of the improvement of diabetes in T2DM rats after duodenal-jejunal bypass （DJB）, and identify the effects of weight changes and gut hormones that might be involved.