Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review

作     者：Feixuan Wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang Feixuan Wang;Jingqiong Wan;Yangzhen Liao;Shangyu Liu;Yuan Wei;Zhen Ouyang

作者机构：School of PharmacyJiangsu UniversityZhenjiang 212013China Nanjing Institute of Product Quality InspectionNanjing 210019China School of Food and Biological EngineeringJiangsu UniversityZhenjiang 212013China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第6期

页      面：2151-2174页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：funded by the National Key Research and Development Program of China(2018YFC1706105) the National Natural Science Foundation of China(81872961) Key Project at Central Government Level(2060302) Collaborative Innovation Project of Dendrobium Industrialization Development in Anhui Province. 

主　　题：Dendrobium species Nutraceutical role Energy homeostasis Neurodegenerative diseases 

摘      要：Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment.The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases.Dendrobium species(‘Shihu’in Chinese)such as D.officinale,D.huoshanense,D.nobile,D.chrysanthum,D.loddigesii,D.moniliforme,D.gratiosissimum,D.candidum and D.caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders.These dietary herbs and their derived compounds possess a variety of biological properties,such as suppression of oxidative stress and neuroinflammation,regulation of energy homeostasis mainly through improving brain mitochondria function,insulin signaling and lipid metabolism.Furthermore,they reduce neurotoxicity,alleviate brain injury and neuropathy,and prevent neurodegenerative conditions including stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease in humans and/or rodents.Moreover,the nutraceuticals from Dendrobium species promote gut health and aid digestion,which appear to be associated with beneficial effects on brain energy homeostasis.Based on the above-mentioned health benefits associated with Dendrobium species,this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions.