3D-Printed Janus Piezoelectric Patchesfor Sonodynamic Bacteria Elimination and Wound Healing

作     者：Danqing Huang Yi Cheng Guopu Chen Yuanjin Zhao Danqing Huang;Yi Cheng;Guopu Chen;Yuanjin Zhao

作者机构：Institute of Translational Medicinethe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2023年第6卷第3期

页      面：335-344页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：the National Key Research and Development Program of China(2020YFA0908200) the National Natural Science Foundation of China(52073060 and 81720108022) the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054) the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038) 

主　　题：patch dynamic piezoelectric 

摘      要：Management of infected wounds has raised worldwide *** in this field focus on the development of intelligent patches for improving the wound ***,inspired by the cocktail treatment and combinational therapy stratagem,we present a novel Janus piezoelectric hydrogel patch via 3-dimensional printing for sonodynamic bacteria elimination and wound *** top layer of the printed patch was poly(ethylene glycol)diacrylate hydrogel with gold-nanoparticle-decorated tetragonal barium titanate encapsulation,which realizes the ultrasound-triggered release of reactive oxygen species without leaking *** bottom layer is fabricated with methacrylate gelatin and carries growth factors for the cell proliferation and tissue *** on these features,we have demonstrated invivo that the Janus piezoelectric hydrogel patch can exert substantial infection elimination activity under the excitation of ultrasound,and its sustained release of growth factors can promote tissue regeneration during wound *** results indicated that the proposed Janus piezoelectric hydrogel patch had practical significance in sonodynamic infection alleviation and programmable wound healing for treating different clinical diseases.