Neural Correlates of Spatial Navigation in Primate Hippocampus

作     者：Dun Mao 

作者机构：Center for Excellence in Brain Science and Intelligent TechnologyInstitute of NeuroscienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第2期

页      面：315-327页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Science and Technology Innovation 2030 Major Program(2022ZD0205000) the Lingang Lab(LG202105-01-08). 

主　　题：Spatial navigation Primate Hippocampus Theta activity Mixed selectivity Task dependency Eye and head coordinates 

摘      要：The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats.Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions.In contrast,investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation.However,recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents,albeit some similarities.Here,we review empirical studies examining the neural correlates of spatial navigation in the primate(including human)hippocampus at the levels of local field potentials and single units.The lower frequency theta oscillations are often intermittent.Single neuron responses are highly mixed and task-dependent.We also discuss neuronal selectivity in the eye and head coordinates.Finally,we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks.