Multiple-model GWAS identifies optimal allelic combinations of quantitative trait loci for malic acid in tomato

作     者：Wenxian Gai Fan Yang Liangdan Yuan Saeed ul Haq Yaru Wang Ying Wang Lele Shang Fangman Li Pingfei Ge Haiqiang Dong Jinbao Tao Fei Wang Xingyu Zhang Yuyang Zhang Wenxian Gai;Fan Yang;Liangdan Yuan;Saeed ul Haq;Yaru Wang;Ying Wang;Lele Shang;Fangman Li;Pingfei Ge;Haiqiang Dong;Jinbao Tao;Fei Wang;Xingyu Zhang;Yuyang Zhang

作者机构：National Key Laboratory for Germplasm Innovation and Utilization of Horticultural CropsHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan LaboratoryWuhan 430070China College of HorticultureNorthwest A&F UniversityYangling 712100China Department of HorticultureThe University of Agriculture PeshawarPeshawar 25130Pakistan 

出 版 物：《Horticulture Research》 (园艺研究（英文）)

年 卷 期：2023年第10卷第4期

页      面：23-37页

核心收录：

学科分类：09[农学] 0902[农学-园艺学] 090202[农学-蔬菜学] 

基　　金：supported by grants from the National Key Research&Development Plan(2022YFD1200502 2021YFD1200201) the National Natural Science Foundation of China(31972426 31991182) the Wuhan Biological Breeding Major Project(2022021302024852) the Key Project of Hubei Hongshan Laboratory(2021hszd007) the Hubei Key Research&Development Plan(2022BBA0062 2022BBA0066) the Fundamental Research Funds for the Central Universities(2662022YLPY001)and the International Cooperation Promotion Plan of Shihezi University(GJHZ202104) 

主　　题：breeding GWAS metabolism 

摘      要：Malic acid(MA)is an important flavor acid in fruits and acts as a mediator in a series of metabolic *** is important to understand the factors affecting MA metabolism for fruit flavor improvement and to understand MA-mediated biological ***,themetabolic accumulation of MA is controlled by complex heredity and environmental factors,making it difficult to predict and regulate the metabolism of *** this study,we carried out a genome-wide association study(GWAS)on MA using eight milestone models with two-environment repeats.A series of associated SNP variations were identified from the GWAS,and 15 high-confidence annotated geneswere further predicted based on linkage disequilibrium and lead *** transcriptome data of candidate geneswere explored within different tomato organs as well as various fruit tissues,and suggested specific expression patterns in fruit *** on the genetic parameters of population differentiation and SNP distribution,tomato MA content has been more influenced by domestication sweeps and less affected by improvement sweeps in the long-term history of tomato *** addition,genotype×environment interaction might contribute to the difference in domestication phenotypic data under different *** study provides new genetic insights into how tomato changed its MA content during breeding and makes available function-based markers for breeding by marker-assisted selection.