Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module

作     者：Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang Dacheng Wang;Lirong Wei;Ting Liu;Jinbiao Ma;Keyi Huang;Huimin Guo;Yufen Huang;Lei Zhang;Jing Zhao;Kenichi Tsuda;Yiming Wang

作者机构：Key Laboratory of Biological Interactions and Crop HealthDepartment of Plant PathologyNanjing Agricultural UniversityNanjing 210095China Key Laboratory of Integrated Management of Crop Disease and PestsMinistry of EducationNanjing Agricultural UniversityNanjingChina State Key Laboratory of Agricultural MicrobiologyHubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2023年第16卷第5期

页      面：903-918页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

基　　金：supported by grants from the National Key Research and Development Project(2022YFE0198100) National Natural Science Foundation of China(32172420) Natural Science Foundation of Jiangsu Province(SBK20220085) Fundamental Research Funds for the Central Universities(KYXK202009,ZJ21195012) the Startup Fund for Distinguished Scholars from Nanjing Agricultural University(to Y.W.) 

主　　题：PAMP-triggered immunity effector-triggered immunity MAPK,WRKY18 protein phosphatase 

摘      要：Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against *** PTI and ETI are intimately connected,the underlying molecular mechanisms remain *** this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae *** DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in ***-activated protein kinases(MAPKs)are key signaling regulators of PTI and *** absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein ***,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 *** together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI.