Emerging Nano-/Biotechnology Drives Oncolytic Virus-Activated and Combined Cancer Immunotherapy
作者机构：Central Laboratory and Department of UrologyShanghai Tenth People’s HospitalTongji University School of MedicineTongji UniversityNo.301 Yan-chang-zhong RoadShanghai 200072China National Center for International Research of Bio-targeting TheranosticsGuangxi Medical UniversityNo.22 Shuangyong Road 22NanningGuangxi 530021China Department of UrologyShanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineNo.639 Zhizaoju RoadHuangpuShanghai 200011China.
出 版 物：《Research》 (研究（英文）)
年 卷 期：2023年第2023卷第4期
页 面：515-538页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Outstanding Youth Science Fund Project of the National Natural Science Foundation of China(grant no.82022033) Shanghai Rising-Star Program(grant no.19QA1406800) Shanghai Talent Development Fund(grant no.2019040) the Fundamental Research Funds for the Central Universities(22120210561) the program for Shanghai Young Top-Notch Talent
主 题：approval insight antitumor
摘 要：Oncolytic viruses(OVs)as one promising antitumor methods have made important contributions to tumor immunotherapy,which arouse increasing *** provide the dual mechanisms including direct killing effect toward tumor cells and immune activation for elevating antitumor responses,which have been proved in many preclinical ***,natural or genetically modified viruses as clinical immune preparations have emerged as a new promising approach objective to oncology *** approval of talimogene laherparepvec(T-VEC)by the *** and Drug Administration(FDA)for the therapy of advanced melanoma could be considered as a milestone achievement in the clinical translation of *** this review,we first discussed the antitumor mechanisms of OVs with an emphasis on targeting,replication,and *** further outlined the state of the art of current OVs in tumor and underlined the activated biological effects especially including *** significantly,the enhanced immune responses based on OVs were systematically discussed from different perspectives such as combination with immunotherapy,genetic engineering of OVs,integration with nanobiotechnology or nanoparticles,and antiviral response counteraction,where their principles were shed light *** development of OVs in the clinics was also highlighted to analyze the actuality and concerns of different OV applications in clinical *** last,the future perspectives and challenges of OVs as an already widely accepted treatment means were *** review will provide a systematic review and deep insight into OV development and also offer new opportunities and guidance pathways to drive the further clinical translation.
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