Architecture of severe fever with thrombocytopenia syndromevirus

作     者：Zixian Sun Jing Cheng Yuan Bai Lin Cao Daoxin Xie Fei Deng Xinzheng Zhang Zihe Rao Zhiyong Lou Zixian Sun;Jing Cheng;Yuan Bai;Lin Cao;Daoxin Xie;Fei Deng;Xinzheng Zhang;Zihe Rao;Zhiyong Lou

作者机构：Department of Basic ResearchGuangzhou LaboratoryGuangzhou 510005China MOE Key Laboratory of Protein ScienceSchool of MedicineTsinghua UniversityBeijing 100084China University of Chinese Academy of SciencesBeijing100049China National Laboratory of BiomacromoleculesCAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China National Virus Resource CenterWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China State Key Laboratory of Medicinal Chemical Biology and College of Life Science and PharmacyNankai UniversityTianjin 300350China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2023年第14卷第12期

页      面：914-918页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by grants from the National Program on Key Research Project of China(2018YFE0200402) the National Natural Science Foundation of China(32188101 and U20A20135) the National Program on Key Research Project of China(2020YFA0707500),and Tsinghua University Spring Breeze Fund 

主　　题：fever mortality 

摘      要：Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS)is an acute infectious disease caused by severe fever with thrombocytopenia syndrome virus(SFTSV)and is characterized by rapid onset,high mortality and widespread *** fatality rate can be as high as 10%-30%,which is significantly higher than that of the hemorrhagic fever caused by Hantavirus in the same area(Song et al.,2018).However,no effective treatments or vaccines are available yet,and the underlying pathogenic mechanisms of the virus are poorly understood.