Role of the adipocyte immune brain axis in Parkinson's disease:friend or foe?

作     者：Martin Regensburger Thomas M.Kinfe Martin Regensburger;Thomas M.Kinfe

作者机构：Division of Molecular NeurologyFriedrich Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Center for Rare Diseases Erlangen(ZSEER)University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Division of Functional Neurosurgery and StereotaxyFriedrich-Alexander University(FAU)Erlangen-NürnbergErlangenGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第11期

页      面：2399-2400页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：MR is a fellow of the Clinician Scientist Programme (IZKF,University Hospital Erlangen) Deutsche Forschungsgem einschaft (German Research Foundation 270949263/GRK21 62) BMBF funded TreatHSP consortium (01GM1905B) 

主　　题：intake Figure 

摘      要：The classical role of adipocytokines is a negative feedback mechanism,providing information about bodily energy reserves to the brain,and thus controlling satiety and food intake (Campfield et al.,1995).Adipose tissue forms the largest endocrine organ of the *** the initial description of leptin and its receptor,LEPR/OBR,with its main active isoform OBRb,there was an initial hope for a drugable pathway to counteract the increasing burden of overweight/adiposity,metabolic syndrome,and related disorders (Figure1).