局部免疫抑制剂治疗亚洲儿童白癜风

作     者：Kanwar A.J. Dogra S. Parsad D. 田中伟 

作者机构：Dermatol. Venereol./Lepr ol. Postgrad. Inst. of Med. Educ./Res.Chandigarh-160012India 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第5期

页      面：54-54页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：儿童白癜风 局部免疫抑制剂 寻常型白癜风 紊乱性 局部应用 有节 灼热感 平均持续时间 

摘      要：Childhood vitiligo is a common disorder of pigmentation in India. Considering the lack of uniformly effective and safe treatment modalities for children with vitiligo, search for newer therapeutic agents continues. This study was designed to evaluate the role of topical tacrolimus in the treatment of childhood vitili go. Twenty-five children with vitiligo were treated with topical 0.03%tacrolim us ointment applied twice daily for 12 weeks. Response was noted as marked to co mplete ( 75%repigmentation), moderate (50-75%repigmentation) and mild ( 5 0%repigmentation). Twenty-two children (9 boys and 13 girls) of mean age 7.2 ±1.4 years completed the study. Twelve (54.5%) children had vitiligo vulgaris, nine (40.9%) had focal vitiligo and one (4.5%) had segmental vitiligo. The me an duration of disease was 8 ±3 months. Nineteen (86.4%) children showed some repigmentation at the end of 3 months and other three had no response. Of these 19 children, repigmentation was markedtocompletein11(57.9%),moderateinfive(26.3 %)and mild in three (15.7%) children. Side effects were minimal, such as the p ruritus and burning noted in only three patients. Topical tacrolimus is an effec tive and well-tolerated treatment modality in Asian children with vitiligo.