Clinicopathological features and expression of regulatory mechanism of the Wnt signaling pathway in colorectal sessile serrated adenomas/polyps with different syndrome types

作     者：Dan Qiao Xiao-Yan Liu Lie Zheng Ya-Li Zhang Ren-Ye Que Bing-Jing Ge Hong-Yan Cao Yan-Cheng Dai 

作者机构：Department of GastroenterologyShanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of GastroenterologyTraditional Chinese Medicine Hospital of Xi’anXi’an 730000Shaanxi ProvinceChina Institute of Digestive DiseasesLonghua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第9期

页      面：1963-1973页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China,No.81873253 the Shanghai Natural Science Foundation,No.22ZR1458800 the Hongkou District Health Committee,No.HKZK2020A01 the Xinglin Scholar Program of Shanghai University of Traditional Chinese Medicine,No.23 

主　　题：Sessile serrated adenomas/polyps Wnt signaling pathway Large intestine damp-heat syndrome Spleen-stomach weakness syndrome 

摘      要：BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide,with the fourth highest mortality among all ***,in addition to adenomas,serrated polyps,which account for 15%-30%of CRCs,can also develop into CRCs through the serrated *** serrated adenomas/polyps(SSAs/Ps),a type of serrated polyps,are easily misdiagnosed during *** To observe the difference in the Wnt signaling pathway expression in SSAs/Ps patients with different syndrome *** From January 2021 to December 2021,patients with SSAs/Ps were recruited from the Endoscopy Room of Shanghai Traditional Chinese Medicine-Integrated Hospital,affiliated with Shanghai University of Traditional Chinese *** cases each of large intestine damp-heat(Da-Chang-Shi-Re,DCSR)syndrome and spleen-stomach weakness(Pi-Wei-Xu-Ruo)syndrome were *** comparison of the general data,typical tongue coating,colonoscopy findings,and hematoxylin and eosin findings was performed in each *** expression of the Wnt pathway-related proteins,namelyβ-catenin,adenomatous polyposis coli,and mutated in colorectal cancer,were analyzed using *** Significant differences were observed with respect to the SSAs/Ps size between the two groups of patients with different syndrome types(P=0.001).The other aspects did not differ between the two *** Wnt signaling pathway was activated in patients with SSAs/Ps belonging to both groups,which was manifested asβ-catenin protein translocation into the ***,SSAs/Ps patients with DCSR syndrome had more nucleation,higherβ-catenin expression,and negative regulatory factor(adenomatous polyposis coli and mutated in colorectal cancer)expression(P0.0001)than SSA/P patients with Pi-Wei-Xu-Ruo *** addition,the SSA/P size was linearly correlated with the related protein *** Patients with DCSR syndrome had a more obvious Wnt signaling pathway activation and a higher ri