CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese
CTLA-4基因A/G多态性与西北地区汉族人糖尿病的相关性研究(英文)作者机构：兰州医学院附属一院内分泌科兰州730000 四川大学第一大学医院普通外科成都610041
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2002年第115卷第8期
页 面：1248-1250,157-158页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Immunoconjugates Polymorphism, Genetic Antigens, Differentiation China Diabetes Mellitus Humans
摘 要：OBJECTIVE: To investigate the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene A/G polymorphism with susceptibility to diabetes mellitus in Han Chinese. METHODS: An A/G transition at position 49 of exon 1 was analyzed in 31 patients with type 1 diabetes, 31 patients with type 2 diabetes, and 36 controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS: A highly significant increase in the frequency of the G allele was seen in patients with type 1 diabetes compared with controls (66.1 % vs. 34.7%, respectively; P
维普期刊数据库
同方期刊数据库