Role of noncoding RNAs in liver fibrosis
作者机构：Department of Clinical MedicineNorth Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Center for Transfusion-transmitted Infectious DiseasesInstitute of Blood TransfusionChinese Academy of Medical Sciences and Peking Union Medical CollegeChengdu 610052Sichuan ProvinceChina Liver Center and Gastrointestinal DivisionDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Department of Clinical LaboratoryThe Hospital of Xidian GroupXi’an 710077Shaanxi ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第9期
页 面：1446-1459页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Science and Technology Innovation Talent Project of Sichuan Province,No.2022JDRC0047 the Central Government-directed Special Funds for Local Science and Technology Development Project,No.2021ZYD0085 Natural Science Foundation of China,No.82102383 Qin Chuangyuan Recruited High-level Innovation and Entrepreneurship Talents Project of Science and Technology Department of Shaanxi Province,No.QCYRCXM-2022-56
主 题：MicroRNAs Long noncoding RNAs Circular RNAs Liver fibrosis Diagnosis Treatment
摘 要：Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive *** is a dynamic and reversible process characterized by the activation of hepatic stellate cells and excess accumulation of extracellular *** fibrosis could lead to cirrhosis and even liver cancer,which has become a significant health burden *** studies have revealed that noncoding RNAs(ncRNAs),including microRNAs,long noncoding RNAs and circular RNAs,are involved in the pathogenesis and development of liver fibrosis by regulating signaling pathways including transforming growth factor-βpathway,phosphatidylinositol 3-kinase/protein kinase B pathway,and Wnt/β-catenin *** in serum or exosomes have been reported to tentatively applied in the diagnosis and staging of liver fibrosis and combined with elastography to improve the accuracy of *** mimics,ncRNAs in mesenchymal stem cell-derived exosomes,and lipid nanoparticles-encapsulated ncRNAs have become promising therapeutic approaches for the treatment of liver *** this review,we update the latest knowledge on ncRNAs in the pathogenesis and progression of liver fibrosis,and discuss the potentials and challenges to use these ncRNAs for diagnosis,staging and treatment of liver *** these will help us to develop a comprehensive understanding of the role of ncRNAs in liver fibrosis.
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