Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis:Is it the magic bullet?

作     者：Dennis Yang Peter V Draganov 

作者机构：Division of GastroenterologyHepatology and NutritionDepartment of MedicineUniversity of FloridaGainesvilleFL 32610United States 

出 版 物：《世界胃肠病学杂志：英文版》 (World Journal of Gastroenterology)

年 卷 期：2012年第18卷第31期

页      面：4082-4085页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Center for Advancing Translational Sciences, NCATS, (UL1TR000064) National Center for Advancing Translational Sciences, NCATS 

主　　题：急性胰腺炎 药物预防 吲哚美辛 内镜 造影 胆管 随机对照试验 知识水平 

摘      要：Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography(ERCP).Pancreatic duct stent insertion after ERCP has been widely accepted as the standard of care for the prevention of this complication in high-risk ***,the placement of pancreatic stents requires higher level of endoscopic expertise and is not always feasible due to anatomic ***,effective non-invasive pharmacologic prophylaxis remains appealing,particularly if it is inexpensive,easily administered,has a low risk side effect profile and is widely *** have been multiple studies evaluating potential pharmacologic candidates for post-ERCP pancreatitis(PEP) prophylaxis,most of them yielding disappointing results.A recently published large,multicenter,randomized controlled trial reported that in high risk patients a single dose of rectal indomethacin administered immediately after the ERCP significantly decreased the incidence of PEP compare to placebo.