Gender difference of clinical characteristics in Chinese patients with spontaneous variant angina

作     者：ZHU Cheng-gang LI Jian-jun XU Yan-lu YUAN Jin-qing QIN Xue-wen YANG Yue-jin QIAO Shu-bin CHEN Ji-lin CHEN Zai-jia GUO Yuan-lin GAO Zhan ZHENG Xin 

作者机构：Department of Cardiology Fu Wai Hospital Peking UnionMedical College and Chinese Academy of Medical SciencesBeijing 100037 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第11期

页      面：1377-1381页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This research was partly supported by grants from Fu Wai Hospital (No. 2004190)  National Natural Science Foundation of China (No. 30670861 and No. 30871055)  Beijing Natural Science Foundation (No. 7082081)  and Specialized Research Fund for the Doctoral Program of High Education of China (No. 20060023044 and No. 20070023047) 

主　　题：coronary spasm coronary artery disease gender 

摘      要：Background Spontaneous attack of variant angina （VA） is a unique component of coronary artery disease （CAD）, and associated with severe cardiac events. However, no data are available regarding sex differences in Chinese patients with spontaneous attacks of VA. Accordingly, the present retrospective study was initiated to evaluate the Clinical characteristics of Chinese female patients with spontaneous attacks of VA. Methods From January 2003 to January 2008, a total of 209 patients were diagnosed to have had a spontaneous attack of VA at Fu Wai Hospital. Of them, 27 were female, and their clinical findings were collected and compared with male patients for aspects of risk factors, clinical features and angiographical findings. Results Spontaneous attacks of VA was relatively uncommon in female （12.9%） compared with male patients. The female patients were less likely to have a history of smoking （14.8% vs. 79.7%, P 〈0.001）, more likely to have a family history of CAD （33.3% vs. 11.0%, P 〈0.01）, and to have had a greater incidence of ventricular fibrillation during attack （11.1% vs. 2.2%, P 〈0.05）. There were no significant differences in other characteristics between the two groups. Conclusion Chinese female patients who experienced a spontaneous attack of VA had the characteristics of less smokina history, more family history of CAD and higher occurrence of ventricular fibrillation than male patients.