Antioxidant,antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract

作     者：Md Atiar Rahman Md Saiful Islam 

作者机构：Department of Biochemistry and Molecular BiologyUniversity of ChittagongChittagong-4331Bangladesh Department of BiochemistrySchool of BiochemistryGenetics and MicrobiologyUniversity of KwaZulu-Natal.(Westville Campus)Durban 4000South Africa 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2013年第3卷第4期

页      面：273-279页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Chittagong University Research Cell(Ref No.5194/Res/Dir/CU/2011) 

主　　题：Leucas aspera Radical scavenging Antibacterial Cytotoxic Probit 

摘      要：Objective:To investigate the antioxidant,antibacterial and cytotoxic activity of whole Leucas aspera(Labiatae)(***)alcoholic ***:Whole *** powder was extracted by absolute ethanol(99.50%).The ethanolic extract was subjected to antioxidant,antibacterial and brine shrimp lethality ***:The extract showed potent radical scavenging effect(antioxidant)with IC_(50)value of(99.58±1.22)μg/mL which was significant(P0.01)in comparison to ascorbic acid with IC_(50)value of(1.25±0.95)μg/*** case of antibacterial screening,the extract showed notable antibacterial effect against the tested microbial ***(P0.05)zone of inhibitions against Gram positive Bacillus subtilis[(12.00±1.32)mm]and Bacillus megaterium[(13.00±1.50)mm],Staphylococcus aureus[(8.00±0.50)mm]and Gram negative Salmonella typhi[(6.00±0.50)mm],Salmonella paratyphi[(8.00±1.00)mm],Shigella dysenteriae[(9.00±1.32)mm]and Vibrio cholerae[(9.00±0.66)mm]was *** brine shrimp lethality bioassay,the extract showed the LC_(50)value as(181.68±2.15)μg/mL which was statistically significant(P0.01)compared to positive control vincristine sulfate[LC_(50)=(0.76±0.04)μg/mL].Conclusions:The results demonstrate that the ethanolic extract of *** could be used as antibacterial,pesticidal and various pharmacologic actives.