Survival and an overview of decision-making in patients with cholangiocarcinoma

作     者：Hvard Mjφrud Forsmo Arild Horn Asgaut Viste Dag Hoem Kjell φvrebφ 

作者机构：Department of SurgeryHaukeland University HospitalBergenNorway Department of Surgical SciencesHaukeland University HospitalBergenNorway 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2008年第7卷第4期

页      面：412-417页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：cholangiocarcinoma survival treatment surgery 

摘      要：BACKGROUND:Cholangiocarcinoma is rare,accounting for approximately 3%of all gastrointestinal *** study aimed to identify the survival rate among surgically treated and palliated patients,and secondly to identify parameters that could predict a curative resection. METHODS:A total of 121 patients,55 men and 66 women, median age 70 years(range 31-91),who had been treated for cholangiocarcinoma in the period of 1990-2005 were evaluated retrospectively. RESULTS:Curative resection was performed in 40 patients (33%),whereas 81 received palliative treatment(67%).16% (19 of 121)of the patients had an explorative laparotomy without tumour *** above 65 years(OR 3.4;95% CI 1.4-8.4;P=0.008),weight loss(OR 8.5;95%CI 1.5-46; P=0.01)or tumour location(The resection rate of hilar cholangiocarcinoma was lower than that of intrapancreatic cancer.)(OR 2.7;95%CI 1.7-4.5;P=0.001)predicted palliative *** adjusted 5-year survival rate of patients who received tumour resection and palliative treatment was 30%and 1.2%,respectively(P0.001).The survival rate of patients who were subjected to hepatectomy (70%)was better than that of patients who had a local or distal resection(20%)(P=0.02). CONCLUSIONS:In few patients with a resectable cholangiocarcinoma,an explorative laparotomy is often necessary to evaluate ***,long-term survival is significantly better in patients who received radical surgical resection.