Effect of High-Altitude Exposure on the Heart

作     者：Lan Huang Lan Huang

作者机构：Institute of Cardiovascular Diseases of People’s Liberation ArmyDepartment of CardiologySecond Affiliated HospitalThird Military Medical University(Army Medical University)Chongqing 400037China 

出 版 物：《Cardiology Discovery》 (心血管病探索（英文）)

年 卷 期：2023年第3卷第1期

页      面：48-53页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(81730054) Military Logistics Research Project,PLA(BLJ18J007) 

主　　题：Altitude High-altitude exposure Hypoxia Cardiac function Pulmonary hypertension 

摘      要：High altitude brings a great physiological change in human beings,both during short-term exposure and in lifelong residents,especially in the cardiovascular *** notably induces pulmonary vasoconstriction,thus resulting in a moderate increase in pulmonary arterial *** inhabitants exhibit lower pulmonary pressure and better exercise capacity than lowlanders during short-term high-altitude *** ascent to high altitude without adequate acclimatization can cause high-altitude pulmonary edema in susceptible individuals,with a rapid increase in pulmonary *** output increases initially following acute high-altitude exposure and returns to normal as at sea level after a few days of *** volumes at high altitude change consistently with decreases in plasma *** ventricular systolic function is enhanced after acute high-altitude exposure and during chronic ***,there are controversies on whether right ventricular systolic function is preserved or decreases after high-altitude exposure,probably due to variable hypoxic pulmonary *** altitude induces altered ventricular diastolic ***,a new perspective has emerged,whereby ventricular intrinsic relaxation is not impaired,as assessed by untwisting through speckle-tracking *** hypoxic pulmonary hypertension probably induced right ventricular dilation and hypertrophy,and even right heart failure,described as high-altitude heart *** to lower altitude should be the best treatment for them,and potential pharmacological agents majorly focus on the inhabitation of pulmonary vasoconstriction,such as phosphodiesterase-5 inhibitors and endothelin receptor *** on the risks of high-altitude exposure for patients with previous cardiovascular diseases is limited,and thus they should be prudent when ascending to high *** randomized large-scale studies are need