Exosome-mediated regulatory mechanisms in skeletal muscle:a narrative review

作     者：Zhaolu WANG Jinjin YANG Xiaohui SUN Xi SUN Gongshe YANG Xin’e SHI Zhaolu WANG;Jinjin YANG;Xiaohui SUN;Xi SUN;Gongshe YANG;Xin'e SHI

作者机构：College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第1期

页      面：1-14页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 0836[工学-生物工程] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(No.2021YFF1000602)。 

主　　题：Exosome Skeletal muscle Muscle atrophy Insulin resistance 

摘      要：Skeletal muscle plays a paramount role in physical activity,metabolism,and energy balance,while its homeostasis is being challenged by multiple unfavorable factors such as injury,aging,or obesity.Exosomes,a subset of extracellular vesicles,are now recognized as essential mediators of intercellular communication,holding great clinical potential in the treatment of skeletal muscle diseases.Herein,we outline the recent research progress in exosomal isolation,characterization,and mechanism of action,and emphatically discuss current advances in exosomes derived from multiple organs and tissues,and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle.These remarkable advances expand our understanding of myogenesis and muscle diseases.Meanwhile,the engineered exosome,as an endogenous nanocarrier combined with advanced design methodologies of biomolecules,will help to open up innovative therapeutic perspectives for the treatment of muscle diseases.