Non-invasive photoacoustic computed tomography of rat heart anatomy and function

作     者：Li Lin Xin Tong Susana Cavallero Yide Zhang Shuai Na Rui Cao Tzung K.Hsiai Lihong V.Wang Li Lin;Xin Tong;Susana Cavallero;Yide Zhang;Shuai Na;Rui Cao;Tzung K.Hsiai;Lihong V.Wang

作者机构：Caltech Optical Imaging LaboratoryAndrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of TechnologyPasadenaCAUSA Department of BioengineeringUCLALos AngelesCAUSA Division of CardiologyDepartment of MedicineUCLALos AngelesCAUSA Present address:College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhouChina Present address:The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2023年第12卷第1期

页      面：109-117页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

基　　金：sponsored by the United States National Institutes of Health(NIH)grants R35 CA220436(Outstanding Investigator Award)and U01 NS099717(BRAIN Initiative) 

主　　题：anatomy hypertensive illumination 

摘      要：Complementary to mainstream cardiac imaging modalities for preclinical research,photoacoustic computed tomography(PACT)can provide functional optical contrast with high imaging speed and ***,PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure(thoracotomy)for tissue ***,we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT(3D-PACT)platform,demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall;thereby,enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 *** further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy,hypertensive,and obese rats,with optical contrast to uncover differences in cardiac chamber size,wall thickness,and ***,3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models,holding promises for clinical translation to cardiac imaging of human neonates.