Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria

作     者：Jade Royo Bertin Vianou Manfred Accrombessi Elisée Kinkpé Linda Ayédadjou Ida Dossou-Dagba YéléLadipo Maroufou Jules Alao Gwladys I.Bertin Michel Cot Farid Boumédiène Sandrine Houzé Jean François Faucher Agnès Aubouy 无 

作者机构：UMR152 PHARMADEVIRDUPSToulouse University35 Chemin Des Maraichers31400 ToulouseFrance Clinical Research Institute of Benin(IRCB)Abomey CalaviBenin Faculty of Infectious and Tropical DiseasesDisease Control DepartmentLondon School of Hygiene and Tropical MedicineLondonUK Paediatric DepartmentCalavi HospitalCalaviBenin Paediatric DepartmentMother and Child University and Hospital Center(CHU-MEL)CotonouBenin UMR261 MERITIRDParis UniversityParisFrance UMR 1094 EpiMaCTInsermLimoges University HospitalLimoges UniversityLimogesFrance French Malaria Reference CenterAPHPBichat HospitalParisFrance Parasitology LaboratoryAPHPBichat-Claude-Bernard HospitalParisFrance Infectious Diseases and Tropical Medicine DepartmentLimoges University HospitalLimogesFrance NeuroCM Group 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2023年第12卷第1期

页      面：47-61页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100202[医学-儿科学] 10[医学] 

基　　金：This work was supported by a grant from the French National Research Agency(ANR-17-CE17-0001) including a PhD grant for Jade Royo.Bertin Vianou received a PHD grant called Research grant for a thesis in the South(ARTS)from the Institut de Recherche pour le Développement France(IRD) 

主　　题：Cerebral malaria Children Benin Cytokine Plasma Urine Immunologic marker NeuroCM 

摘      要：Background Cerebral malaria(CM)is a neuropathology which remains one of the deadliest forms of malaria among African *** kinetics of the pathophysiological mechanisms leading to neuroinflammation and the death or survival of patients during CM are still poorly *** increasing production of cytokines,chemokines and other actors of the inflammatory and oxidative response by various local actors in response to neuroinflammation plays a major role during CM,participating in both the amplification of the neuroinflammation phenomenon and its *** this study,we aimed to identify risk factors for CM death among specific variables of inflammatory and oxidative responses to improve our understanding of CM *** Children presenting with CM(n=70)due to *** infection were included in southern Benin and divided according to the clinical outcome into 50 children who survived and 20 who *** examination was complemented by fundoscopic examination and extensive blood biochemical analysis associated with molecular diagnosis by multiplex PCR targeting 14 pathogens in the patients cerebrospinal fluid to rule out *** technology and enzyme immunoassay kits were used to measure 17 plasma and 7 urinary biomarker levels,*** were analysed by univariate analysis using the nonparametric Mann-Whitney U test and Pearson’s Chi2 *** and multivariate analyses were conducted separately for plasma and urinary biomarkers to identify CM mortality risk *** Univariate analysis revealed higher plasma levels of tumour necrosis factor(TNF),interleukin-1beta(IL-1β),IL-10,IL-8,C-X-C motif chemokine ligand 9(CXCL9),granzyme B,and angiopoietin-2 and lower urinary levels of prostanglandine E2 metabolite(PGEM)in children who died compared to those who survived CM(Mann-Whitney U-test,P-values between 0.03 and0.0001).The multivariate logistic analysis highlighted elevated plasma levels of IL-8 as the m