Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

作     者：Xianyun Wang Shiqi Hu Dashuai Zhu Junlang Li Ke Cheng Gang Liu Xianyun Wang;Shiqi Hu;Dashuai Zhu;Junlang Li;Ke Cheng;Gang Liu

作者机构：Department of CardiologyThe First Hospital of Hebei Medical UniversityShijiazhuang 050000China Scientific Research Data CenterThe First Hospital of Hebei Medical UniversityShijiazhuang 050000China Hebei Key Laboratory of Cardiac Injury Repair Mechanism StudyShijiazhuang 050000China Hebei International Joint Research Center for Structural Heart DiseaseShijiazhuang 050000China Department of Molecular Biomedical ScienceNorth Carolina State UniversityRaleigh 27607North CarolinaUSA Department of Biomedical EngineeringUniversity of North CarolinaChapel Hill and North Carolina State UniversityRaleigh 27607North CarolinaUSA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第5期

页      面：7248-7259页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0835[工学-软件工程] 10[医学] 

基　　金：NC State University,the National Natural Science Foundation of China(No.82200276) the Grant of Key Research and Development Program of Hebei Province(No.203777117D) the Key Project of Hebei Provincial Health Commission(Nos.20201159 and 20180224) the Natural Science Foundation of Hebei Province(Nos.H2021206399 and H2022206295) 

主　　题：nanovesicles(NVs) exosomes,cardiac repair mesenchymal stem cells(MSCs) extracellular vesicles(EVs) myocardial infarction(MI) 

摘      要：Extracellular vesicles(EVs)generated from mesenchymal stem cells(MSCs)play an essential role in modulating cell–cell communication and tissue *** clinical translation of EVs is constrained by the poor yield of *** has recently become an effective technique for producing a large scale of nanovesicles(NVs).In this study,we systematically compared MSC NVs(from extrusion)and EVs(from natural secretion).Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than ***,microRNAs in NVs are related to cardiac repair,fibrosis repression,***,intravenous delivery of MSC NVs improved heart repair and cardiac function in a mouse model of myocardial infarction.