Pervasive Translation of Circular RNAs

出 版 物：《Bulletin of the Chinese Academy of Sciences》 (中国科学院院刊（英文版）)

年 卷 期：2022年第36卷第2期

页      面：71-72页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：doubt sponge nearby 

摘      要：Circular RNAs(circRNAs)are prevalent in animals and plants and are created through the back-splicing of *** thought to be by-products,the discovery of circRNA’s hidden roles in gene regulation has led to a greater understanding of their *** molecules may act as molecular sponges by sequestering miRNAs or RNA binding proteins,or may promote the transcription of nearby *** research has shown that circRNAs require the internal ribosomal entry site(IRES)for translation in a capindependent mechanism due to the lack of a 5’***,the research community does not share a common opinion on the existence of IRESs in eukaryotic transcriptomes,casting doubts on the scope of circRNA translation.