Sudden Cardiac Death and Cardiac Sodium Channel Diseases

作     者：Wenzhao Wei Ying Fang Nan Zhou Qiuping Wu Qianhao Zhao Jianding Cheng 

作者机构：Department of Forensic PathologyZhongshan School of MedicineSun Yat‑sen UniversityGuangzhouChina 

出 版 物：《Journal of Forensic Science and Medicine》 (法庭科学与法医学杂志（英文）)

年 卷 期：2022年第8卷第4期

页      面：179-185页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Brugada syndrome dilated cardiomyopathy long QT syndrome progressive cardiac conduction disorder sodium channel disease sudden cardiac death 

摘      要：Sudden cardiac death(SCD),accounting for a substantial part of the forensic autopsy,is a leading cause of mortality *** arrhythmia due to sodium channel diseases is recognized as one of the most prevalent etiologies of *** these disorders,defective cardiomyocytes,including the pacemaker and the working cardiomyocytes,would manifest as abnormal electrical activity and morphology,thereby predisposing individuals to *** is always a problem for forensic pathologists to adjudicate a sudden death caused by sodium channel diseases since structural changes in those cases are often *** the advent of the molecular autopsy,forensic pathologists can conduct targeted gene testing to identify the risk of SCD for family members of the *** review aims to discuss the relationship between SCD and sodium channel diseases,clarify the underlying mechanisms,and provide prophylactic suggestions for the relatives of SCD patients at risk.