Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder

作     者：Ancha Baranova Vikas Chandhoke Hongbao Cao Fuquan Zhang Ancha Baranova;Vikas Chandhoke;Hongbao Cao;Fuquan Zhang

作者机构：School of Systems BiologyGeorge Mason UniversityFairfaxVirginiaUSA Research Centre for Medical GeneticsMoscowRussian Federation Institute of NeuropsychiatryThe Affiliated Brain Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of PsychiatryThe Affiliated Brain Hospital of Nanjing Medical UniversityNanjingJiangsuChina 

出 版 物：《General Psychiatry》 (综合精神医学（英文）)

年 卷 期：2023年第36卷第2期

页      面：106-113页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：diabetes overlap causal 

摘      要：Background Type 2 diabetes(T2D)is a chronic metabolic disorder with high comorbidity with mental *** genetic links between attention-deficit/hyperactivity disorder(ADHD)and T2D have yet to be *** We aim to assess shared genetics and potential associations between ADHD and *** We performed genetic correlation,two-sample Mendelian randomisation and polygenic overlap analyses between ADHD and *** genome-wide association study(GWAS)summary results of T2D(80154 cases and 853816 controls),ADHD2019(20183 cases and 35191 controls from the 2019 GWAS ADHD dataset)and ADHD2022(38691 cases and 275986 controls from the 2022 GWAS ADHD dataset)were used for the *** T2D dataset was obtained from the DIAGRAM *** ADHD datasets were obtained from the Psychiatric Genomics *** compared genome-wide association signals to reveal shared genetic variation between T2D and ADHD using the larger ADHD2022 ***,molecular pathways were constructed based on large-scale literature data to understand the connection between ADHD and *** T2D has positive genetic correlations with ADHD2019(rg=0.33)and ADHD2022(rg=0.31).Genetic liability to ADHD2019 was associated with an increased risk for T2D(odds ratio(OR):1.30,p0.001),while genetic liability to ADHD2022 had a suggestive causal effect on T2D(OR:1.30,p=0.086).Genetic liability to T2D was associated with a higher risk for ADHD2019(OR:1.05,p=0.001)and ADHD2022(OR:1.03,p0.001).The polygenic overlap analysis showed that most causal variants of T2D are shared with ADHD2022.T2D and ADHD2022 have three overlapping *** pathway analysis suggests that ADHD and T2D could promote the risk of each other through inflammatory *** Our study demonstrates substantial shared genetics and bidirectional causal associations between ADHD and T2D.