Mitochondria-targeted cancer therapy based on functional peptides

作     者：Yuhan Sun He Zhang Guangzhao Lu Huan Wang Ying Lu Li Fan Yuhan Sun;He Zhang;Guangzhao Lu;Huan Wang;Ying Lu;Li Fan

作者机构：Department of Pharmaceutical SciencesSchool of PharmacyNaval Medical UniversityShanghai 200433China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第5期

页      面：104-110页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Peptides Mitochondria Cancer therapy Targeting Cell uptake 

摘      要：Mitochondria are critical for tumor growth and metastasis.A number of traditional antitumor drugs have poor water solubility and must penetrate multiple cellular barriers to reach the *** mitochondria have a unique transmembrane potential and an inner membrane with a low permeability,it is difficult for most drugs to enter *** recent years,mitochondria-targeted delivery systems that use functional peptides to modify drugs have received increasing *** functional peptides can change the original physicochemical properties of drugs and actively target *** peptide-drug conjugates(PDCs,peptide-drug conjugates)can decompose and release drugs over time or due to certain stimuli in *** preserves the biological activity of the drug while increasing intratumor uptake through the enhanced permeability and retention effect(EPR,the enhanced permeability and retention effect).In this review,we focus on the direction of cancer therapy and review the application of different functional peptides in the mitochondria-targeted tumor treatments reported in recent years.