Low-dose aspirin in the prevention of pre-eclampsia in China: postpartum hemorrhage in subgroups of women according to their characteristics and potential bleeding risk

作     者：Jiahui Chen Jing Huai Li Lin Boya Li Yuchun Zhu Huixia Yang 

作者机构：Department of Obstetrics and GynecologyPeking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes MellitusBeijing 100034China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第5期

页      面：550-555页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：Major Program of the National Natural Science Foundation of China(No.81490745) State Key Development Program for Basic Research of China(No.2015CB943304) 

主　　题：APPEC study Aspirin Postpartum hemorrhage Body mass index Pre-eclampsia 

摘      要：Background:The APPEC study is a large-population randomized controlled trial in China evaluating the role of low-dose aspirin prophylactic treatment for *** was no statistically significant difference in postpartum hemorrhage(PPH)incidence between the aspirin and control *** study aimed to evaluate the potential bleeding risk of 100 mg aspirin in high-risk pregnant women and the difference in the incidence of PPH according to maternal ***:This is a secondary data analysis of the APPEC *** counts and coagulation test results were collected at five follow-up *** defined by maternal age(35 years and≥35 years),pre-pregnancy body mass index(pre-BMI,28 kg/m 2 and≥28 kg/m 2),parity,gestational age at enrollment,and medical history,including pre-eclampsia,chronic hypertension,and diabetes mellitus,were *** regression analysis was used to determine the statistical significance of the difference in the incidence of PPH after aspirin administration in pregnant women in each *** using multiple logistic regression models followed these *** logistic regression was used to determine the relationship between pre-BMI and ***:There was no significant difference between the aspirin and control groups in bleeding risk(3.4%[16/464]vs.3.0%[13/434],T=0.147,P=0.701).No significant difference was found in the incidence of PPH in total(relative risk=1.220,95%confidence interval[CI]=0.720–2.067,P=0.459;aspirin group *** group,6.5%[30/464]vs.5.3%[23/434],P=0.459)or in subgroup analysis.A significant correlation between pre-BMI and PPH was found in the aspirin group,while in the control group there was no significant correlation(aspirin group,odds ratio[OR]=1.086,95%CI=1.004–1.175,P=0.040;control group,OR=1.060,95%CI=0.968–1.161,P=0.209).Conclusions:A dosage of 100 mg of aspirin per day,initiated from 12 to 20 gestational weeks until 34 weeks of gestation,did not increa