Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

作     者：Wenkai Ren Junfeng Ban Yaoyao Xia Fang Zhou Caihong Yuan Huanhuan Jia Hailan Huang Mingmin Jiang Minjian Liang Zhaodong Li Youyong Yuan Yulong Yin Hong Wu 

作者机构：State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesLaboratory for Lingnan Modern AgricultureSouth China Agricultural UniversityGuangzhou 510642China Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Natural MedicineSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Advanced Drug Delivery SystemsGuangdong Pharmaceutical UniversityGuangzhou 510006China Sericulture&Agri-Food Research Institute Guangdong Academy of Agricultural SciencesKey Laboratory of Functional FoodsMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510640China Key Laboratory of Guangdong Laboratory AnimalsGuangdong Laboratory Animals Monitoring InstituteGuangzhou 510663China School of Biomedical Sciences and EngineeringSouth China University of TechnologyGuangzhou International CampusGuangzhou 511442China Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 511442China 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2023年第4卷第2期

页      面：68-76,67页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Key Realm R&D Program of Guangdong Province(2020B020221001) the Open Competition Program of Ten Major Directions of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG07) Chinese Academy of Science Key Project(QYZDY-SSW-SMC008) National Natural Science Foundation of China grants(32225047,31922079,32130099) 

主　　题：purpurea macrophage analysis. 

摘      要：Echinacea purpurea modulates tumor progression,but the underlying mechanism is poorly *** isolated and purified a novel homogeneous polysaccharide from ***(EPPA),which was shown to be an arabinogalactan with a mean molecular mass(Mr)of 3.8×10^(4)Da and withα-(1→5)-L-Arabinan as the backbone and a-L-Araf-(1→,→6)-b-D-Galp-(1→,and →4)-α-D-GalpA-(1/as the side ***,oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile(e.g.,facilitating M1 macrophages)in tumor micro-environment by single-cell RNA sequencing(scRNA-seq)analysis.