Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation
作者机构：Department of Colorectal and Anal SurgerySuqian Hospital of Traditional Chinese MedicineSuqian 223800Jiangsu ProvinceChina College of Clinical MedicineGuizhou University of Traditional Chinese MedicineGuiyang 550000Guizhou ProvinceChina Department of Colorectal and Anal SurgeryThe First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550000Guizhou ProvinceChina
出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)
年 卷 期：2023年第14卷第2期
页 面：4-21页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by the "333 Scientific Project" of Jiangsu Province in 2020, No. BRA2020237 the Science and Technology Project of Suqian, Jiangsu Province in 2020, No. Z2020057
主 题：Slow transit constipation Cinnamic acid Intestinal microbiome Short-chain fatty acids Intestinal motility
摘 要：BACKGROUND Slow transit constipation(STC)is a disorder with delayed colonic *** acid(CA)is an organic acid in natural plants,such as Radix Scrophulariae(Xuan Shen),with low toxicity and biological activities to modulate the intestinal *** To explore the potential effects of CA on the intestinal microbiome and the primary endogenous metabolites-short-chain fatty acids(SCFAs)and evaluate the therapeutic effects of CA in *** Loperamide was applied to induce STC in *** treatment effects of CA on STC mice were assessed from the 24 h defecations,fecal moisture and intestinal transit *** enteric neurotransmitters:5-hydroxytryptamine(5-HT)and vasoactive intestinal peptide(VIP)were determined by the enzyme-linked immunosorbent ***-eosin and Alcian blue and Periodic acid Schiff staining were used to evaluate intestinal mucosa s histopathological performance and secretory function.16S rDNA was employed to analyze the composition and abundance of the intestinal *** SCFAs in stool samples were quantitatively detected by gas chromatography-mass *** CA ameliorated the symptoms of STC and treated STC *** ameliorated the infiltration of neutrophils and lymphocytes,increased the number of goblet cells and acidic mucus secretion of the *** addition,CA significantly increased the concentration of 5-HT and reduced *** significantly improved the diversity and abundance of the beneficial ***,the production of SCFAs[including acetic acid(AA),butyric acid(BA),propionic acid(PA)and valeric acid(VA)]was significantly promoted by *** changed abundance of Firmicutes,Akkermansia,Lachnoclostridium,Monoglobus,UCG.005,Paenalcaligenes,Psychrobacter and Acinetobacter were involved in the production of AA,BA,PA and *** CA could treat STC effectively by ameliorating the composition and abundance of the intestinal microbiome to regulate the production of SCFAs.
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