Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats
作者机构：Department of PainHebei General HospitalShijiazhuang 050051HebeiChina Department of Geriatric CardiologyHebei General HospitalShijiazhuang 050051HebeiChina Department of CardiologyThe Third Hospital of Shijiazhuang City affiliated with Hebei Medical UniversityShijiazhuang 050011HebeiChina
出 版 物：《Cardiovascular Innovations and Applications》 (心血管创新与应用（英文）)
年 卷 期：2022年第7卷第3期
页 面：92-101页
学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学]
基 金：supported by grants from the 2019 Hebei Science and Technology Project(grant number19277787D) 2019 Hebei Innovation Capability Promotion Project(grant number 199776249D)
主 题：ferroptosis heart failure SGLT2 inhibitors AMPK
摘 要：Aims:Sodium-glucose cotransporter-2(SGLT2)inhibitors have been found to ameliorate major adverse cardiovascular events in patients with heart failure with preserved ejection fraction(HFpEF),but the exact mechanism is *** is a form of programmed ***,we verified that canagliflozin(CANA)ameliorates heart function in HFpEF rats,partly by regulating ferroptosis,which may be activated by AMPK/PGC-1α/Nrf2 ***:An HFpEF model was established and subjected to CANA *** pressure was monitored,and echocardiography was performed at the 12th *** examination was performed,and expression of ferroptosis-associated proteins and AMPK/PGC-1α/Nrf2 signaling related proteins was ***:CANA had an antihypertensive effect and increased E/A ratios in HFpEF *** pathology was ameliorated,on the basis of decreased cross-sectional area and intercellular ***-CoA synthetase longchain family member 4(ACSL4)expression increased,whereas ferritin heavy chain 1(FTH1)expression decreased in HFpEF rats,which showed iron *** reversed changes in ACSL4 and FTH1,and decreased iron accumulation,but did not alter glutathione peroxidase 4(GPX4)*** expression of AMPK/PGC-1α/Nrf2 signaling related proteins and heme oxygenase 1(HO-1)in the HFpEF group decreased but was reverted after CANA ***:CANA regulates ferroptosis,potentially via activating AMPK/PGC-1α/Nrf2 signaling in HFpEF rats.
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