Electrochemical detection of amino acids based on cucurbit[7]uril-mediated three-dimensional gold nanoassemblies

作     者：Shimi Liu Hao Zhang Yaqi Wang Yan Zeng Sobhan Chatterjee Feng Liang Shimi Liu;Hao Zhang;Yaqi Wang;Yan Zeng;Sobhan Chatterjee;Feng Liang

作者机构：The State Key Laboratory of Refractories and MetallurgySchool of Chemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhan 430081China Improve-WUST Joint Laboratory of Advanced Technology for Point-of-Care Testing and Precision MedicineWuhan University of Science and TechnologyWuhan 430081China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第4期

页      面：258-261页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported in part by grants from the National Natural Science Foundation of China (No. 21871108) the Program for Innovative Teams of Outstanding Young and Middle-Aged Researchers in the Higher Education Institutions of Hubei Province(No. T201702) 

主　　题：Cucurbituril Gold nanoassemblies Amino acids Electrochemical detection Host-guest interactions 

摘      要：In this paper, cucurbit[7]uril(CB[7])-mediated three-dimensional gold nanoassemblies were successfully prepared to increase the loaded amount of CB[7] and enhance the electrochemical detection of amino acids. Particle sizes of gold nanoparticles(Au NPs) significantly affect stability and detection sensitivity of nanoassemblies. The volume of gold nanoassemblies first increased and then decreased with the increase of CB[7] concentration. The 3D gold nanoassemblies composed of 16 nm Au NPs and 100 μmol/L CB[7]had excellent stability and maximum volume, exhibiting more sensitive detection for a variety of amino acids. And the detection limits of aromatic amino acids are lower in virtue of the higher binding constant between aromatic amino acids and CB[7]. This study will develop and deepen our understanding of molecular recognition in amino acids detection.