The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise

作     者：Abram Katz 

作者机构：Åstrand LaboratoryDepartment of PhysiologyNutrition and BiomechanicsThe Swedish School of Sport and Health SciencesGIHStockholmSweden 

出 版 物：《运动医学与健康科学(英文)》 (Sports Medicine and Health Science)

年 卷 期：2023年第5卷第1期

页      面：29-33页

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 

主　　题：Phosphorylase Glycogen Glycogen synthase Muscle Exercise 

摘      要：Initially it was believed that phosphorylase was responsible for both glycogen breakdown and synthesis in the living *** discovery of glycogen synthase and McArdle s disease(lack of phosphorylase activity),together with the high Pi/glucose 1-P ratio in skeletal muscle,demonstrated that glycogen synthesis could not be attributed to reversal of the phosphorylase ***,glycogen synthesis was attributable solely to the activity of glycogen synthase,subsequent to the transport of glucose into the ***,the well-established observation that phosphorylase was inactivated(i.e.,dephosphorylated)during the initial recovery period after prior exercise,when the rate of glycogen accumulation is highest and independent of insulin,suggested that phosphorylase could play an active role in glycogen *** the quantitative contribution of phosphorylase inactivation was not established until recently,when studying isolated murine muscle preparations during recovery from repeated contractions at temperatures ranging from 25 to 35
***,in both slow-twitch,oxidative and fast-twitch,glycolytic muscles,inactivation of phosphorylase accounted for 45%–75%of glycogen accumulation during the initial hours of recovery following repeated *** data indicate that phosphorylase inactivation may be the most important mechanism for glycogen accumulation under defined *** results support the initial belief that phosphorylase plays a quantitative role in glycogen formation in the living ***,the mechanism is not via activation of phosphorylase,but rather via inactivation of the enzyme.