A tightly bonded reduced graphene oxide coating on magnesium alloy with photothermal effect for tumor therapy

作     者：Lidan Liu Feng Peng Dongdong Zhang Mei Li Jian Huang Xuanyong Liu 

作者机构：State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Department of OrthopedicsGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Chemistry and Materials ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou 310024China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2022年第10卷第11期

页      面：3031-3040页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 0806[工学-冶金工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：financially supported by the National Natural Science Foundation of China (31771044) China Postdoctoral Science Foundation (2019M662830) Shanghai Committee of Science and Technology,China (19JC1415500,18ZR1445000) International Partnership Program of Chinese Academy of Sciences (GJHZ1850) Natural Science Foundation of Guangdong Province,China (2020A1515011447)。 

主　　题：Magnesium alloy Reduced graphene oxide Photothermal effect 

摘      要：Photothermal therapy becomes a hotspot in the treatment of bone tumors. Magnesium and its alloys are regarded as potential bone implants for their favorable mechanical property and biodegradable in vivo. However, there is few research devoted to fabricating a photothermal coating on Mg alloy. In the present study, reduced graphene oxide coating with a strong photothermal effect was prepared on the surface of AZ31via two steps. Firstly, graphene oxide coating was deposited on the surface via electrophoresis deposited(GO#), followed by a reduction process of the graphene oxide coating in ultrapure water(rGO#). GO# and rGO# coatings were characterized by SEM, Raman, XRD, FTIR,and XPS. The results revealed that, compared with GO# coating, the content of oxygen-containing(C-O/C-O-C, C=O, O-C=O) groups on rGO# coating was significantly decreased. rGO# coating was found tightly adhered to AZ31 substrate. According to the first-principles calculations, the well-bonded heterostructure between MgO and rGO is the main reason for the strong bonding force. Moreover, the prepared rGO# coating showed a superior photothermal effect, which brings a new strategy to the treatment of bone tumors with Mg-based implants.