Manifestation of the malignant progression of glioma following initial intracerebral hemorrhage:A case report

作     者：En-Xi Xu Si-Yuan Lu Bo Chen Xiao-Dong Ma Er-Yi Sun 

作者机构：Department of NeurosurgeryThe Affiliated People’s Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of RadiologyThe Affiliated People’s Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of AnesthesiaThe Affiliated People’s HospitalZhenjiang 212002Jiangsu ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第7期

页      面：1576-1585页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Zhenjiang Municipal Health Commission No.SH2019081 

主　　题：Intracranial hemorrhage Glioma Glioneuronal tumor Rare Case report 

摘      要：BACKGROUND Intracranial hemorrhage is extremely rare during the initial stages of ***,we report a case of glioma with unclassified pathology and intracranial *** SUMMARY After the second surgery for intracerebral hemorrhage,the patient experienced weakness in the left arm and leg,but could walk *** month after discharge,the weakness in the left limbs had exacerbated and the patient also suffered from headaches and dizziness.A third surgery was ineffective against the rapidly growing *** hemorrhage may be the initial symptom of glioma in some rare cases,and atypical perihematomal edema can be used for diagnosis during an *** histological and molecular features seen in our case were similar to that of glioblastoma with a primitive neuronal component,which is termed diffuse glioneuronal tumor with features similar to oligodendroglioma and nuclear clusters(DGONC).The patient underwent three surgeries to remove the *** first tumor resection had been performed when the patient was *** of the hemorrhage and bone disc decompression were performed when the patient was *** month after the last discharge,the patient underwent neuronavigation-assisted resection of the right frontotemporal parietal lesion plus extended flap *** the 50^(th)d after the third operation,computed tomography imaging showed rapid tumor growth accompanied by brain *** patient was discharged and died 3 d *** Glioma can present as bleeding in the initial stage and should be considered in such a *** have reported a case of DGONC,which is a rare molecular subtype of glioma with a unique methylation profile.