Clinical implications of COVID-19 in patients with metabolicassociated fatty liver disease

作     者：Mohammad Sadiq Jeeyavudeen Rahul Chaudhari Joseph M Pappachan Sherouk Fouda 

作者机构：Department of Endocrinology and MetabolismUniversity Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Department of GastroenterologyHepatology and NutritionVirginia Commonwealth UniversityRichmondVA 23298United States Department of Endocrinology and MetabolismLancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of ScienceManchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom School of Health and Biomedical SciencesRMIT UniversityMelbourne VICAustralia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第3期

页      面：487-502页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Metabolic-associated fatty liver disease COVID-19 Metabolic syndrome Non-alcoholic steatohepatitis Angiotensin converting enzyme 2 

摘      要：People across the world are affected by thecoronavirus disease 2019(COVID-19),brought on by theSARS-CoV type-2 coronavirus.Due to its high incidence in individuals with diabetes,metabolic syndrome,and metabolic-associated fatty liver disease(MAFLD),COVID-19 has gained much attention.The metabolic syndrome s hepatic manifestation,MAFLD,carries a significant risk of type-2-diabetes.The link between the above two conditions has also drawn increasing consideration since MAFLD is intricately linked to the obesity epidemic.Independent of the metabolic syndrome,MAFLD may impact the severity of the viral infections,including COVID-19 or may even be a risk factor.An important question is whether the present COVID-19 pandemic has been fueled by the obesity and MAFLD epidemics.Many liver markers are seen elevated in COVID-19.MAFLD patients with associated comorbid conditions like obesity,cardiovascular disease,renal disease,malignancy,hypertension,and old age are prone to develop severe disease.There is an urgent need for more studies to determine the link between the two conditions and whether it might account for racial differences in the mortality and morbidity rates linked to COVID-19.The role of innate and adaptive immunity alterations in MAFLD patients may influence the severity of COVID-19.This review investigates the implications of COVID-19 on liver injury and disease severity and viceversa.We also addressed the severity of COVID-19 in patients with prior MAFLD and its potential implications and therapeutic administration in the clinical setting.