High-gain signal-on PEDOT:PSS organic photoelectrochemical transistor biosensing modulated by a MXene/MOFs/NiO Schottky heterojunction

作     者：Zheng Li Yi-Tong Xu Jin Hu Ting Wang Fang-Qing Liu Hong Zhou Guang-Xu Chen Peng Lin Wei-Wei Zhao Jing-Juan Xu Hong-Yuan Chen 

作者机构：State Key Laboratory of Analytical Chemistry for Life ScienceSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Shenzhen Key Laboratory of Special Functional Materials&Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen518060China Shandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao266042China School of Environment and EnergyState Key Laboratory of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSouth China University of TechnologyGuangzhou510006China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第2期

页      面：578-585页

核心收录：

学科分类：07[理学] 070304[理学-物理化学(含∶化学物理)] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(22034003,21974059,22174063) the Excellent Research Program of Nanjing University(ZYJH004) the State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2203)。 

主　　题：signal-on PEDOT:PSS organic electrochemical transistor biosensing Schottky heterojunction 

摘      要：Herein we report a high-gain signal-on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)organic electrochemical transistor(OECT)biosensing using an accumulation-mode PEDOT:PSS OECT modulated by a light-fueled MXene/MOFs/Ni O Schottky heterojunction.In such a system,the MXene/MOFs/Ni O Schottky heterojunction exhibited superior gating effect,as it not only enabled the fast-directional charge transfer but also guaranteed the maximal accessibility of the electrolyte to topped 2D MXene with large surface area.In linkage with a bi-enzyme cascade system,the quinone derivatives produced by the cascade reaction of alkaline phosphatase(ALP)and tyrosinase(TYR)could serve as effective electron acceptors for the representative Ti_(3)C_(2)/PCN-224/Ni O heterojunction,underpinning an innovative method for sensitive detection of ALP activity with a low detection limit of 0.001 U L^(-1).Remarkably,the as-developed system demonstrated a remarkable current gain as high as near 10^(4),which to our knowledge is the highest one among existing OECT biosensory devices.This work represents a generic protocol to develop the novel signal-on PEDOT:PSS OECT platform towards biochemical detection and beyond.